Veto T cells enhance engraftment allogeneic hematopoietic stem cells / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 824-827, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-313886
Responsible library:
WPRO
ABSTRACT
Veto activity was defined as the capacity of specifically downregulating cytotoxic T-precursor cell (CTL-p) directed against antigens of the veto cells themselves but not against third-party antigens. Many studies have shown that the most potent veto cells are CD8(+) cytotoxic T lymphocytes (CD8(+)CTLs). Effectively, CD8(+)CTLs of donor origin can facilitate engraftment of donor's stem cells by eliminating host-alloreactive T lymphocytes. In this article, effect mechanisms, depletion of GVH ex vivo, application in vivo, synergistic enhancement with rapamycin and regulatory T cells, and anti-tumor effect in the hematopoietic stem cell transplantation are summarized.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
T-Lymphocytes, Cytotoxic
/
Hematopoietic Stem Cell Transplantation
/
Immune Tolerance
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2011
Document type:
Article