Relationship between serum galectin-3 levels and mortality of subacute on chronic liver failure / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 295-298, 2014.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-314050
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the correlation between clinically detected serum galectin-3 levels and prognosis of liver failure.</p><p><b>METHODS</b>Fifty-five patients diagnosed with liver failure were administered a combined modality therapy and followed up until death or for 6 months. Fifty-five patients with liver failure were administered a combined modality therapy and followed up until death or for 6 months. In addition, 30 patients with chronic hepatitis B (CHB) and 30 healthy volunteers were matched for use as controls. Serum galectin-3 levels were detected at baseline and last follow-up visit and compared between groups by statistical analysis.</p><p><b>RESULTS</b>At baseline, the CHB group had a significantly higher level of serum galectin-3 than the healthy control group (F=2.701, P less than 0.01). However, the galectin-3 level 5 of the liver failure group was significantly higher than that of both the CHB group (F=8.121, P less than 0.01) and the healthy control group (F=11.231, P less than 0.01). When patients within the liver failure group were divided by survival and death occurring during the 6-month follow-up period, the patients who died (n=28) were found to have a significantly higher level of serum galectin-3 than the surviving patients (n=27) (P less than 0.01). The area under the curve of ROC curve is 0.766, and cut off value is 0.246 5 ng/ml.</p><p><b>CONCLUSION</b>The level of serum galectin-3 is positively correlated with risk of death in patients with liver failure. Up-regulation of galectin-3 may act as a protective factor in patients with severe liver injury.</p>
Full text:
Available
Health context:
SDG3 - Target 3.3 End transmission of communicable diseases
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Hepatitis
/
Digestive System Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Prognosis
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Blood
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Case-Control Studies
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Liver Failure
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Hepatitis B, Chronic
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Galectin 3
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Diagnosis
Type of study:
Diagnostic study
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Observational study
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Prognostic study
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Risk factors
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2014
Document type:
Article