Long term outcome of acute myeloid leukemia with t(8;21) / 中华血液学杂志
Chinese Journal of Hematology
; (12): 186-191, 2009.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-314502
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence factors on survival and outcome of acute myeloid leukemia (AML) patients with t(8;21).</p><p><b>METHODS</b>Eighty seven AML patients with t(8;21) after long-term follow-up were enrolled in the analysis of clinical feature, immunophenotype, chromosome karyotype, treatment regimen, as well as the overall survival (OS) and relapse-free survival (RFS).</p><p><b>RESULTS</b>The overall complete remission (CR) rate was 95.3%. CR rate after first course therapy was 69.8%, after first course therapy containing medium dose Ara-C was 86.2%, and after first course of therapy containing standard-dose Ara-C was 60.3%. The median OS duration was 16.4 months, median RFS 11.7 months, 3 year OS rate 42%, 5 year OS rate 39%, 3 year RFS rate 55% and 5 year RFS rate 55%. Male gender chromosome 9q(-) had statistical significance for shorter OS and poor outcome, 2 courses of post-remission therapy with intermediate dose Ara-C, induction therapy with intermediate-dose Ara-C and post-remission with 4 courses consolidation therapy had statistically longer OS and RFS.</p><p><b>CONCLUSION</b>Sex, chromosome karyotype, induction and consolidation therapy were important influence factors on OS and RFS. Application of intermediate dose Ara-C to induction and consolidation therapy leads to a higher CR rate, prolong OS and RFS.</p>
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Congenital and Chromosomal Anomalies
/
Leukemia
Database:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Translocation, Genetic
/
Leukemia, Myeloid, Acute
/
Survival Rate
/
Mortality
/
Treatment Outcome
/
Diagnosis
/
Genetics
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2009
Document type:
Article