Regulative mechanism of renal inflammatory-related p38MAPK signaling pathway in diabetic nephropathy and interventional effects of Chinese herbal medicine / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2268-2272, 2013.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-315045
Responsible library:
WPRO
ABSTRACT
It is reported, in the process of diabetic nephropathy (DN), inflammatory-related p38 mitogen-activated protein kinase (MAPK) signaling pathway has a close relationship with renal injury. On the one hand,many factors in the upstream including hyperglycemia, abnormal hemodynamics, oxidative stress, and pro-inflammatory cytokines could activate p38MAPK signaling pathway. On the other hand,the activated p38MAPK signaling pathway could lead to renal damage via activating inflammatory cells, inducing the expression of inflammatory mediators, and intervening cytokines production. CHM could intervene p38MAPK signaling pathway through multi-ways, including inhibiting inflammatory cytokines expression, regulating phosphorylated p38MAPK (p-p38MAPK) expression, and reducing fibrogenic factors expression.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Drugs, Chinese Herbal
/
Signal Transduction
/
Inflammation Mediators
/
P38 Mitogen-Activated Protein Kinases
/
Diabetic Nephropathies
/
Drug Therapy
/
Inflammation
/
Kidney
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2013
Document type:
Article