Ginkgolide B inhibits carotid sinus baroreflex in anesthetized male rats / 生理学报
Acta Physiologica Sinica
; (6): 17-22, 2008.
Article
in En
| WPRIM
| ID: wpr-316766
Responsible library:
WPRO
ABSTRACT
The effects of ginkgolide B on the carotid sinus baroreflex (CSB) were studied in the perfused isolated carotid sinus of 30 anesthetized Sprague-Dawley male rats. The results were as follows. (1) By perfusing with ginkgolide B (0.1, 1, 10 μmol/L), the functional curve of the baroreflex was shifted to the right and upward. There was a marked decrease in peak slope (PS) and reflex decrease (RD) in mean arterial pressure (P<0.01), while the threshold pressure (TP), equilibrium pressure (EP) and saturation pressure (SP) were significantly increased (P<0.05, P<0.01). Among the functional parameters of CSB, the changes in PS, RD, TP, EP and SP were dose-dependent. (2) Pretreatment with Bay K8644 (500 nmol/L), an agonist of L-type calcium channel, completely eliminated the effects of ginkgolide B (1 μmol/L) on the CSB. (3) Pretreatment with tetraethylammonium (TEA, 1 mmol/L), an inhibitor of potassium channel, completely abolished the above effects of ginkgolide B (1 μmol/L) on the CSB. These results suggest that ginkgolide B inhibits the CSB in anesthetized rats, which is mediated by decreased calcium influx and increased potassium efflux in baroreceptor nerve endings.
Full text:
1
Database:
WPRIM
Main subject:
Pharmacology
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Pressoreceptors
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Calcium Channel Agonists
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3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
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Carotid Sinus
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Rats, Sprague-Dawley
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Baroreflex
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Tetraethylammonium
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Calcium Channels, L-Type
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Potassium Channel Blockers
Limits:
Animals
Language:
En
Journal:
Acta Physiologica Sinica
Year:
2008
Document type:
Article