Expression of Matrix Metalloproteinase (MMP)-2, MMP-9, Tissue Inhibitor of Metalloproteinase (TIMP)-1 and TIMP-2 in Adenocarcinomas of The Gallbladder
Korean Journal of Pathology
; : 1-9, 2003.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-31753
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Matrix metalloproteinase (MMP)-2 and MMP-9 degrade type IV collagen and are antagonized by the tissue inhibitors of metalloproteinase (TIMP)-2 and TIMP-1, respectively.METHODS:
We studied by immunohistochemistry the expressions of MMP-2, MMP-9, TIMP-1 and TIMP-2 in 72 cases of adenocarcinoma of the gallbladder.RESULTS:
The MMP-2, MMP-9 and TIMP-1 expressions were significantly higher in well/moderately differentiated adenocarcinomas than in poorly differentiated adenocarcinomas, in adenocarcinomas that had invaded the lamina propria/proper muscle than in those that had invaded the perimuscular connective tissue or beyond the serosa, and in adenocarcinomas with fungating growth than in those with infiltrative growth. The TIMP-2 expression showed a similar pattern without statistical significance. Regarding the status of lymph node metastasis, the MMP-2 expression was significantly higher in cases without lymph node metastasis. The MMP-2 and MMP-9 expressions were significantly related to those of TIMP-2 and TIMP-1, respectively, with regard to depth of invasion, differentiation, and growth patterns of the adenocarcinomas.CONCLUSIONS:
MMP-2, MMP-9, TIMP-1 and TIMP-2 are suggested to play important roles in the progression to early invasion of adenocarcinomas, in which the function of MMP-2 is inhibited by TIMP-2.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Serous Membrane
/
Immunohistochemistry
/
Adenocarcinoma
/
Connective Tissue
/
Tissue Inhibitor of Metalloproteinases
/
Tissue Inhibitor of Metalloproteinase-1
/
Tissue Inhibitor of Metalloproteinase-2
/
Matrix Metalloproteinases
/
Collagen Type IV
/
Gallbladder
Language:
Korean
Journal:
Korean Journal of Pathology
Year:
2003
Document type:
Article