Distribution and antibiotics resistance related to nosocomial pathogenic bacteria infection in patients after cardiac surgery / 中华流行病学杂志

ABSTRACT

Objective To investigate the clinical distribution and antibiotics resistance of nosocomial infection caused pathogenic bacteria in patients after cardiac surgery.Methods Clinical data from 612 patients after cardiac surgery under microbiologically documented nosocomial infection was retrospectively analyzed from January 2007 to December 2012.Identification on related bacterial was performed in an automatic ATB Expression system while antimicrobial susceptibility was tested by Kirby-Bauer method.Results were analyzed by WHONET5.4.Results There were 697 strains of clinical pathogenic bacilli isolates identified and 421 (60.4％) of them were isolated from sputum while 185 (26.5％) were from blood.Acinetobacter spp.(124 strains,17.8％),Pseudomonas aeruginosa (85 strains,12.2％) and Klebsiella pneumoniae (50 strains,7.2％) were the predominant Gramnegative bacilli while S.epidermidis (75 strains,10.8％) was the predominant Gram-positive cocci.The predominant eumycete was Candida albicaas (43 strains,6.2％).Results from the susceptibility test showed that carbopenems,cefoperazone/sulbactam and piperacillin/tazobactam were the most active antibiotics.The detection of meticillin-resistant Staphylococcus (MRS) were 82.9％ in S aureus and 95.9％ in coagulase negative Staphylococcus.There was no Staphylococcus strains resistant to vancomycin found.Conclusion Non-fermenting Gram-negative bacilli and Staphylococcus appeared the important pathogens in patients after cardiac surgery.Drug resistance to antibiotics was quite common.Prevention on nosocomial infection and rational use of antibiotics remained very important in reducing the amount of drug resistant strains.