Association between genetic polymorphisms in methylentetrahydrofolate reductase and risk of lung cancer / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 700-703, 2005.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-318833
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between methylentetrahydrofolate reductase (MTHFR) polymorphisms and risk of lung cancer.</p><p><b>METHODS</b>Totally 505 cases with lung cancer and 500 frequency-matched controls were genotyped for the MTHFR C677T and A1298C polymorphisms by polymerase chain reaction-restriction fragment length polymorphism methods. The odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression model. Haplotype frequency was estimated using EH software.</p><p><b>RESULTS</b>The frequency of the MTHFR C677T allele in cases was significantly higher than that in controls (53.5% vs 44.9%, P < 0.001). Compared with the 677CC genotype, the 677CT and 677TT genotypes were associated with increased risk of lung cancer, with the OR being 1.43 (95% CI, 1.04-1.95) and 2.40 (95% CI, 1.61-3.59), respectively. In addition, a significant difference in the distribution of haplotype frequencies between cases and controls was observed.</p><p><b>CONCLUSION</b>Functional polymorphism in MTHFR is associated with increased risk of lung cancer in Chinese population.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
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Case-Control Studies
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Risk
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Genetic Predisposition to Disease
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Methylenetetrahydrofolate Reductase (NADPH2)
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Gene Frequency
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Genetics
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Genotype
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Lung Neoplasms
Type of study:
Etiology study
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Observational study
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Risk factors
Limits:
Adult
/
Aged
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Female
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Humans
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Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2005
Document type:
Article