Gene expression changes of cartilage matrix of condylar cartilage with anterior disc displacement / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the gene expression changes in extracellular matrix of condylar cartilage following disc anterior displacement of rabbit TMJ.</p><p><b>METHODS</b>The right sides of 28 joints in 40 rabbits were subjected to surgical operation of disc displacement. The condylar Collagen II and Aggrecan mRNA expression were detected by in situ hybridization.</p><p><b>RESULTS</b>Collagen II and Aggrecan mRNA mainly expressed in the lower zone of condylar chondrocyte. Aggrecan mRNA decreased faster than collagen II following disc displacement, and adjusted to normal later.</p><p><b>CONCLUSION</b>Anterior disc displacement leads to alteration of extracellurar matrix gene expression in the condylar chondrocyte, which means the start of remodeling.</p>