Effect of sex hormones on secretion of lysozyme in alveolar macrophage / 中国应用生理学杂志

ABSTRACT

<p><b>AIM AND METHODS</b>To further explore the functions of alveolar macrophage and their modulation mechanisms, the activity of lysozyme in rat alveolar macrophage assessed by electrophoresis was determined. The effects of androsterone and estradiol on lysozyme secretion and their mechanisms were also studied.</p><p><b>RESULTS</b>The results showed that androsterone and estradiol increased activity of lysozyme significantly (P < 0.01), indomethacin abolished those effects. This suggests that the insufficiency of sex hormones secretion as the retrogression of gonads is involved in the decrease of immunological functions, and the susceptibility to infectious diseases.</p><p><b>CONCLUSION</b>Sex hormones increased activity of lysozyme, and those effects related to prostaglandin.</p>