Clinicopathologic features and prognostic significance of basal-like breast cancer / 中华病理学杂志
Chinese Journal of Pathology
; (12): 316-322, 2009.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-319738
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyzed a large group of invasive breast cancers with long-term follow-up information to evaluate the clinicopathologic, morphological and prognostic features of basal-like breast cancers in Chinese population.</p><p><b>METHODS</b>Immunohistochemistry was used to detect the expression of ER, HER2, CK5/6, EGFR on tissue microarray with 1311 invasive breast cancers. Based on the results, these cases were categorized into luminal A, luminal B, basal-like, HER2-overexpressing and null subtypes. Clinicopathological features and survival rates were compared between these groups.</p><p><b>RESULTS</b>Basal-like breast cancers constituted 17.0% of 1311 invasive breast cancers with a significantly larger size, higher grade and higher incidence of the medullary carcinoma, frequent recurrence and infrequent node metastasis. Morphologically, basal-like breast cancers showed a significantly more solid architecture and ribbon-like architecture associated with necrosis (more geographic necrosis) and central scar, a more pushing margin, lymphocytic infiltration and a higher mitosis score, more syncytial growth, presence of basaloid cells, spindle cells and squamous metaplasia. The disease-free survival and overall survival of basal-like breast cancers were significantly poorer than that of luminal A subtype, but similar to the other ER-negative subtypes. Basal markers were not independent prognostic factors.</p><p><b>CONCLUSIONS</b>Basal-like breast cancers in Chinese population has a similar prevalence to that of the western populations. They have distinct clinicopathologic features compared to other non-basal breast cancers, but overlapping with other ER-negative breast cancers. Morphological features are strongly associated with basal-like breast cancers although they are not very specific. The survival of basal-like breast cancers is poorer than luminal A, but similar to the other ER-negative breast cancers, and basal markers are not independent prognostic factors of breast cancers.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
General Surgery
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Breast Neoplasms
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Receptors, Estrogen
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China
/
Epidemiology
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Survival Rate
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Follow-Up Studies
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Carcinoma, Ductal, Breast
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Receptor, ErbB-2
Type of study:
Observational study
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Prognostic study
Limits:
Adult
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Aged
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Aged, 80 and over
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Female
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Humans
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Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2009
Document type:
Article