Association between insulin resistance and cholesteryl ester transfer protein gene polymorphism in type 2 diabetes mellitus / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 298-301, 2005.
Article
in Zh
| WPRIM
| ID: wpr-321101
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between cholesteryl ester transfer protein (CETP) gene polymorphism and insulin resistance in type 2 diabetes.</p><p><b>METHODS</b>CETP-TaqIB gene was genotyped with polymerase chain reaction-restriction enzyme fragment polymorphism analysis in 108 patients with type 2 diabetes and in 60 normal controls. Plasma lipids, fasting insulin, insulin sensitivity index and insulin resistance index were determined in 108 patients with type 2 diabetes.</p><p><b>RESULTS</b>The distribution of CETP-TaqIB genotypes and B1B2 allele frequency in the patients with type 2 diabetes were similar to that in general population. High density lipoprotein cholesterol (HDL-C), apolipoprotein A1(apoA1) and insulin sensitivity index (ISI) levels were significantly higher in B2B2 genotype than in B1B1 genotype. Fasting insulin (FINS) and Homeostasis model assessment-insulin resistance (HOMA-IR) levels were significantly lower in B2B2 genotype than in B1B1 genotype. No significant differences in triglyceride (TG), total cholesterol(TC),low density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB) levels were observed among different CETP-TaqIB genotype groups. By multivariate analysis, the determinants of ISI and HOMA-IR were body mass index (BMI), TC, HDL-C and CETP-TaqIB genotype.</p><p><b>CONCLUSION</b>The CETP-TaqIB genotype is independently associated with insulin resistance and lipid metabolism. It may be an important risk factor of insulin resistance in type 2 diabetes.</p>
Full text:
1
Database:
WPRIM
Main subject:
Polymorphism, Genetic
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Insulin Resistance
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Diabetes Mellitus, Type 2
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Lipid Metabolism
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Cholesterol Ester Transfer Proteins
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Gene Frequency
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Genetics
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Genotype
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Metabolism
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2005
Document type:
Article