Predictive value of immunological parameters on sepsis following abdominal operation for patients with HIV infection / 中华胃肠外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study postoperative sepsis in HIV/AIDS patients who underwent abdominal operations.</p><p><b>METHODS</b>A retrospective analysis was performed to study 34 HIV/AIDS patients treated between January 2009 and December 2010 at the Shanghai Public Health Clinical Center Affiliated to Fudan University.</p><p><b>RESULTS</b>There were 31 males and 3 females in this cohort with a mean age of 45±13 years. Nineteen patients developed postoperative sepsis. The levels of preoperative CD4, postoperative CD4, preoperative CD4/CD8, and postoperative platelet were significantly lower than those without sepsis (all P<0.05). Among 19 patients with a preoperative CD4 cell count less than or equal to 200×10(6)/L, the incidence of postoperative sepsis rate was 84.2%(16/19), and for those with a preoperative CD4 cell count greater than 200×10(6)/L, the incidence of postoperative sepsis rate was 20.0%(3/15), the difference was statistically significant(P<0.05). There were 3 postoperative deaths.</p><p><b>CONCLUSION</b>CD4 cell count can be used as a predictive marker for the development of postoperative sepsis in patients with HIV/AIDS.</p>