Effects of bagasse polysaccharide on the immune functions of immunosuppressed mice / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effects of bagasse polysaccharide on the immune functions of immunosuppressed mice.</p><p><b>METHODS</b>Immunosuppressed mouse models were established by intraperitoneal injections with cyclophosphamide followed by daily intragastric administration of bagasse polysaccharide. After the treatments, the mice were examined for immune organ weight index, phagocytotic function of the macrophages, delayed type hypersensitivity, serum IgM level following exposure to chicken red blood cells, formation of hemolytic plaques, T cell percentage and lymphocyte transformation.</p><p><b>RESULTS</b>Treatment of the immunosuppressed mice with bagasse polysaccharide at the daily dose of 200 and 400 mg/kg significantly increased the weight of the immune organs, phagocytotic function of the macrophages, delayed type hypersensitivity, serum IgM level against chicken red blood cells, formation of hemolytic plaques, T cell percentage and lymphocyte transformation.</p><p><b>CONCLUSION</b>Bagasse polysaccharide can enhance the immune functions of immunosuppressed mice.</p>