Emergence of truncated PB1-F2 protein of H3N2 influenza virus during its epidemic period in Jiangsu Province, China / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 1487-1492, 2014.
Article
in En
| WPRIM
| ID: wpr-322242
Responsible library:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>PB1-F2 protein has been proven to increase the pathogenicity of influenza A virus (IAV) strains in primary infection and in secondary bacterial infection. It can also regulate the activity of viral polymerase. However, it was shown in another retrospective study that a portion of IAVs do not express full-length PB1-F2 protein during virus development; different kinds of stop codons cause exits in the open reading frames and form PB1-F2 gene products with the corresponding genotypes. Truncated PB1-F2 in human H3N2 IAVs has long been detected in North America but its evolution in China is still unclear.</p><p><b>METHODS</b>Influenza-like illnesses (ILIs) from the whole of Jiangsu Province were collected and inspected to determine the type and subtype of the viruses. A portion of isolates collected in the epidemic period were selected as samples for later whole-genome sequencing, and the exact sequences were determined and analyzed.</p><p><b>RESULTS</b>H3N2 influenza virus was one of the epidemical strains which had been prevalent during 2009-2010, in Jiangsu. Five H3N2 isolates with truncated PB1-F2 protein (25aa) were detected in influenza samples from Nanjing and Xuzhou, while seven similar H3N2 isolates were also reported in Niigata, Japan.</p><p><b>CONCLUSION</b>This emergence indicates the possibility that there has been transmission of the H3N2 virus between the two countries.</p>
Full text:
1
Database:
WPRIM
Main subject:
Viral Proteins
/
Virology
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Chemistry
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China
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Epidemiology
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Influenza, Human
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Influenza A Virus, H3N2 Subtype
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Genetics
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Metabolism
Type of study:
Observational_studies
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Chinese Medical Journal
Year:
2014
Document type:
Article