Protein-protein interaction network of receptor activator of nuclear factor-kappaB ligand and macrophage colony-stimulating factor induced differentiation of osteoclasts / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 518-521, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-322346
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To systemically investigate receptor activator of nuclear factor-kappaB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) induced differentiation of osteoclasts.</p><p><b>METHODS</b>Mouse protein-protein interaction(PPI) database NIA and published microarray dataset GES16749 were used to construct and analyze PPI network of RANKL and M-CSF induced mouse monocyte RAW264.7.</p><p><b>RESULTS</b>In the PPI network, transforming growth factor beta receptor 1 (TGFBR1), Rous sarcoma oncogene (SRC), myelocytomatosis oncogene(MYC) and integrin beta 3 (ITGB3) were able to interact with more proteins and they were the key nodes in the signaling transduction.</p><p><b>CONCLUSION</b>TGFBR1, SRC, MYC and ITGB3 might be the key points of RANKL and M-CSF induced differentiation of osteoclasts.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Osteoclasts
/
Membrane Glycoproteins
/
Carrier Proteins
/
Cell Differentiation
/
Macrophage Colony-Stimulating Factor
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RANK Ligand
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Receptor Activator of Nuclear Factor-kappa B
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Protein Interaction Maps
Limits:
Animals
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2012
Document type:
Article