Infection of human papillomavirus 16/18 DNA in patients with head and neck squamous cell carcinoma and its relationship with expression of Ki-67 and P53 protein / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 429-432, 2010.
Article
in Zh
| WPRIM
| ID: wpr-322757
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To detect the infection of human papillomavirus (HPV) 16/18 in patients with head and neck squamous cell carcinoma and explore the relationship between HPV infection and expressions of Ki-67 and P53 proteins in tumor tissue.</p><p><b>METHOD</b>The level of HPV 16/18 DNA was measured by real time polymerase chain reaction, and Ki-67 and P53 proteins were measured by immunohistochemistry in tissues from head and neck squamous cell carcinoma.</p><p><b>RESULTS</b>HPV 16/18 DNA was detected in 62.8% of our patients. In each cancer tissue sample, Ki-67 protein was expressed between 2% to 70%. P53 protein was expressed in 46.15% of our patients. No significant relation was found between HPV 16/18 DNA level and sex, smoking, drinking, and tumor clinical stages. However, level of HPV 16/18 DNA was found to have positive relation with tumor pathological grades and negative relation with P53 protein expression. No relation with Ki-67 protein expression was found.</p><p><b>CONCLUSION</b>Head and neck squamous cell carcinoma may be initiated by HPV 16/18 infection and the mechanism in carcinogenesis involves abnormal expression in P53 protein.</p>
Full text:
1
Database:
WPRIM
Main subject:
Virology
/
DNA, Viral
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Carcinoma, Squamous Cell
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Uterine Cervical Neoplasms
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Tumor Suppressor Protein p53
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Ki-67 Antigen
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Human papillomavirus 16
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Human papillomavirus 18
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Metabolism
Limits:
Adult
/
Aged
/
Aged80
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Female
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Humans
/
Male
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2010
Document type:
Article