Study on the relationship between passive smoking and blood lipids, fibrinogen and viscosity among women who never smoke / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 1167-1170, 2007.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-322833
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine whether blood lipids profile, fibrinogen and viscosity were associated with passive smoking (i. e. environmental tobacco smoke, ETS) in Chinese women who never smoke.</p><p><b>METHODS</b>In Xi'an, China, a case-control study was carried out on 115 cases of coronary heart disease (CHD) defined by coronary arteriography (CAG) and 208 non-CHD controls confirmed by CAG and/or exercise electrocardiography. Data on exposure to ETS, defined as exposure from cigarettes smoking husband or co-workers or both for at least 5 years, was obtained through standardized interviews. Standard laboratory methods were used and the lipid measurements were under US CDC quality control programs.</p><p><b>RESULTS</b>In the subjects defined by CAG, the levels of high density lipoprotein cholesterol (HDL-C), HDL2C, apolipoprotein (apo) A1 among passive smokers appeared lower than those in non-passive smokers,but the low density lipoprotein cholesterol (LDL-C), apoB, apoB/A1, fibrinogen, plasma and whole blood viscosity were higher than that in non-passive smokers. There were positive associations of the numbers of coronary arteriosclerosis with the levels of blood lipids,fibrinogen and viscosity. In the non-CHD controls, 81 subjects were not exposed and 127 were exposed to ETS. The P values of t-test for the adjusted (for age, body mass index, present diseases history) means between two groups were listed below 0.06 (total cholesterol), 0.30 (triglyceride), 0.004 (HDL-C), <0.001 (HDL2-C), < 0.001 (apoA1), 0.009 (apoB), <0.001 (apoB/apoA1), <0.001 (fibrinogen), <0.001 (plasma viscosity), <0.001 and 0.004 [two measures (5.75/s and 230/s) of whole blood viscosity]. The correlation coefficients between cumulative exposure of passive smoking and HDL-C,HDL2-C,apoA1, apoB, apoB/apoA1, fibrinogen, plasma viscosity, and two measures of whole blood viscosity were -0.25, -0.27, -0.30, 0.24, 0.31, 0.32, 0.43, 0.51 and 0.36 (all P<0.01), respectively.</p><p><b>CONCLUSION</b>Passive smoking could affect blood lipid metabolism, fibrinogen and viscosity in the never smoking women which might contribute to the causation of coronary heart disease.</p>
Full text:
Available
Health context:
SDG3 - Target 3A Strengthen the implementation of the WHO Framework Convention on Tobacco Control
/
SDG3 - Health and Well-Being
Health problem:
Protection from Exposure
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Target 3.9: Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
Database:
WPRIM (Western Pacific)
Main subject:
Tobacco Smoke Pollution
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Blood
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Blood Viscosity
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Fibrinogen
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Apolipoprotein A-I
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Coronary Disease
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Cholesterol, HDL
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Cholesterol, LDL
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Metabolism
Type of study:
Observational study
Limits:
Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2007
Document type:
Article