A preliminary study of anti-aging and wound healing of recombination cytoglobin / 药学学报
Acta Pharmaceutica Sinica
; (12): 51-57, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-323081
Responsible library:
WPRO
ABSTRACT
In this paper, the preliminary study on antioxidant, enhancement of antioxidant enzymes activity, reducing the content of oxygen free radicals, delaying skin aging of the recombination cytoglobin (rCygb) purified by our lab were investigated through human keratinocyte cell line (HaCAT) H2O2 oxidative stress model, mouse skin aging model caused by continuous subcutaneous injection D-gal, rat acute liver injury model induced by CCl4 and rat skin wound healing model. The results showed that rCygb improved the activities of total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px) and catalase (CAT), reduced the activities of lactate dehydrogenase (LDH) and alanine aminotransferase (ALT) as well as decreased the content of malondialdehyde (MDA). Skin biopsy showed that rCygb promoted angiogenesis, increased expression of collagen and improved the anti-inflammatory ability. All results displayed that rCygb improved the oxygen free radical scavenging ability, delayed skin aging and promoted wound healing.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Superoxide Dismutase
/
Wound Healing
/
Recombinant Proteins
/
Aging
/
Globins
/
Carbon Tetrachloride
/
Catalase
/
Random Allocation
/
Keratinocytes
Type of study:
Controlled clinical trial
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Document type:
Article