Characterization of vinflunine tartrate liposomes in vitro and in vivo / 药学学报
Acta Pharmaceutica Sinica
; (12): 1515-1519, 2011.
Article
in Zh
| WPRIM
| ID: wpr-323092
Responsible library:
WPRO
ABSTRACT
Vinflunine tartrate-loaded liposomes (VT-L) with two drug-to-lipid ratios were prepared by pH gradient method. Vesicle size and zeta potential were determined by the Zetasizer Nano ZS. Entrapment efficiency was evaluated by cation exchange resin centrifugalization method. The toxicity and tumor inhibition to nude mouse administrated by VT-L with different drug-to-lipid ratios were investigated and compared with the vinflunine tartrate injection (VT-I). The results showed that the mean particle size, zeta potential and entrapment efficiency of the VT-L with drug-to-lipid ratios of 1 : 5 and 1 : 10 were 124.6 nm and 128.3 nm, -25.3 mV and -22.8 mV, 94.46% and 97.31%, respectively. The VT-L with two different drug-to-lipid ratios has significantly higher anti-tumor effect to nude mouse transplanted human non-small cell lung carcinoma A549 and lower toxicity than VT-I. While there were no significant differences in anti-tumor effect and toxicity between VT-L with two different drug-to-lipid ratios.
Full text:
1
Database:
WPRIM
Main subject:
Particle Size
/
Pathology
/
Pharmacology
/
Tartrates
/
Vinblastine
/
Drug Carriers
/
Random Allocation
/
Chemistry
/
Drug Delivery Systems
/
Cell Line, Tumor
Type of study:
Clinical_trials
Limits:
Animals
/
Female
/
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Document type:
Article