Studies on absorption kinetics of paeonol and paeonol-beta-CD in rat's intestines / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 35-37, 2008.
Article
in Zh
| WPRIM
| ID: wpr-324304
Responsible library:
WPRO
ABSTRACT
To explore the absorption mechanism of paeonol-beta-CD from various intestinal segments and offer biopharmaceutics data for paeonol new dosage form. The absorption kinetics and permeability rate consatants were investigated by the in situ perfusing method in rats. The absorption of the drug conforms to the firt-order kinetics and passive transport mechanism . The results indicate that paeonol-beta-CD absorption mechanism wasn't change.
Full text:
1
Database:
WPRIM
Main subject:
Acetophenones
/
Physiology
/
Pharmacokinetics
/
Kinetics
/
Rats, Sprague-Dawley
/
Intestinal Absorption
/
Intestines
/
Metabolism
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2008
Document type:
Article