Proton magnetic resonance spectroscopy of the thalamus and hypothalamus in patients with first-episode depression / 南方医科大学学报
Journal of Southern Medical University
; (12): 2442-2445, 2009.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-325095
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the presence of abnormal metabolism in the thalamus and hypothalamus in patients with first-episode depression.</p><p><b>METHODS</b>Thirty drug-naive patients with first-episode depression and 30 age-matched controls were scanned with proton magnetic resonance spectroscopy ((1)H-MRS) for Naa, Cho, Cr and mI.</p><p><b>RESULTS</b>Compared with the control group, the patients showed significantly reduced mI and mI/Cr of the hypothalamus, reduced mI/Cr of the left thalamus, and lowered Cho, ml, and ml/Cr of the right thalamus (P<0.05).</p><p><b>CONCLUSION</b>Patients with first-episode depression may have myo-inositol and phosphoric acid metabolism disorder in the thalamus and hypothalamus with malfunction of cellular osmotic pressure adjustment mechanism. Abnormal mI/Cr in the thalamus and hypothalamus may represent an important biochemical change in advanced patients with depression.</p>
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Mental Health and Behavioral Disorders
Database:
WPRIM (Western Pacific)
Main subject:
Protons
/
Thalamus
/
Magnetic Resonance Spectroscopy
/
Case-Control Studies
/
Choline
/
Creatine
/
Depression
/
Diagnosis
/
Hypothalamus
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Inositol
Type of study:
Diagnostic study
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Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Document type:
Article