B7-H1, a prognostic factor for patient's response to therapy of acute myeloid leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1332-1335, 2012.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-325265
Responsible library:
WPRO
ABSTRACT
This study was aimed to detect the expression of B7-H1 gene in the acute myeloid leukemia (AML) cells and to explore its clinical significance. The B7-H1 gene expression was detected by real-time quantitative PCR in bone marrow mononuclear cells (BMMNC) from 40 newly diagnosed AML patients, 10 normal volunteers and 10 relapsed patients. The results showed that the expression of B7-H1 from de novo AML patients was lower than that from the normal volunteers, but it was higher in the relapsed patients. The expression level of B7-H1 gene before therapy was significantly higher in non CR patients than that in CR patients after therapy. It is concluded that there is a correlation between the expression level of B7-H1 gene and response to therapy.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Leukemia
Database:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Recurrence
/
RNA, Messenger
/
Leukemia, Myeloid, Acute
/
Case-Control Studies
/
Gene Expression
/
Reverse Transcriptase Polymerase Chain Reaction
/
Diagnosis
/
B7-H1 Antigen
/
Genetics
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Experimental Hematology
Year:
2012
Document type:
Article