Study on the antigenicity and HA1 gene characteristics of influenza A viruses during 2004-2008 year in China / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 405-408, 2009.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-325529
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To under stand influenza A viruses epidemic, antigenicity and genetic characteristics variation between the vaccine and Circulation strains during 2004-2008 year in China.</p><p><b>METHODS</b>The influenza A viruses (H1N1, H3N2) isolated from 2004-2008 year were under took antigenic and sequence analysis. Influenza A virus antigenicity and genetic characteristics were analyzed thought amino acid variation compassion of HA1 protein of influenza A virus isolates.</p><p><b>RESULTS</b>The antigenicity of influenza H1N1 subtype viruses isolated from 2004 to 2007 is very similar with vaccine strain A/New Caledonia/20/1999 (HIN1)-like virus. The influenza H1N1 viruses circulated in 2008 year had similar antigenic characteristics with A/Brisben/59/2007 (H1N1) which is component of influenza vaccines for northern hemisphere 2008-2009 year. The influenza H3N2 subtype viruses of 2004-2005 year had antigenic variation comparatively with vaccine strain A/Fujian/411/12002 (H3N2), The antigenicity of 2006-2007 H3N2 viruses and 2008 year's is A/Wiscansin/67/2006(H3N2) and A/ Brisben/10/2006(H3N2) respectively.</p><p><b>CONCLUSION</b>There is change of influenza A viruses (H1N1, H3N2) antigenic and genetic characteristics during 2004-2008 in China.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Phylogeny
/
Virology
/
Antigenic Variation
/
Molecular Sequence Data
/
Cell Line
/
Chemistry
/
China
/
Epidemiology
/
Sequence Alignment
/
Amino Acid Sequence
Limits:
Animals
/
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2009
Document type:
Article