Serum mannan-binding lectin levels in preschool children from Shenzhen / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 149-151, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-325605
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Mannan-binding lectin (MBL) is a C-type serum lectin that plays a central role in the innate immune response. At present there is no a reference range of serum MBL levels for children in China. This study investigated serum MBL levels in preschool children from Shenzhen.</p><p><b>METHODS</b>A total of 118 children (62 boys and 56 girls) at ages of 3-6 years and sampled randomly from three kindergartens of Shenzhen were enrolled in this study. Serum MBL concentrations were determined using enzyme-linked immunosorbent assay.</p><p><b>RESULTS</b>The mean serum MBL concentration in these children was 779.07+/-268.98 ng/mL. There were no significant differences in the value of serum MBL between boys and girls (783.89+/-252.30 ng/mL vs 773.65+/-288.29 ng/mL) (P>0.05). Sixteen children (13.6%) had MBL concentrations less than 500 ng/mL (the low limited value used abroad), including 14 cases with 50-500 ng/mL and 2 cases with less than 50 ng/mL.</p><p><b>CONCLUSIONS</b>This study provides a reference range of serum MBL concentration for preschool children. MBL may be a useful marker for the prevention of infection in children.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Blood
/
Mannose-Binding Lectin
/
Immunity, Innate
Limits:
Child
/
Child, preschool
/
Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2008
Document type:
Article