Expression and clinical significance of cyclin H and CDK7 in human hemangiomas / 中华整形外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expression and clinical significance of cyclin H and cyclin-dependent kinase 7 (CDK7) in human hemangiomas.</p><p><b>METHODS</b>Immunohistochemistry technique was used to measure the expression of cyclin H and CDK7 proteins in proliferative, involuting hemangiomas and normal skin tissues. Immunohistochemical technique for factor VIII-related antigen was used to prove that the cells which expressed cyclin H and CDK7 were endothelial cells. Average optical density and positive area of the expression of cyclin H and CDK7 proteins in proliferative, involuting hemangiomas and normal skin tissues were measured by image analysis (HPIAS-1000).</p><p><b>RESULTS</b>The expression of cyclin H and CDK7 protein in proliferating hemangiomas was significantly higher than that in involuting hemangiomas and normal skin tissues (P < 0.01). But no significant difference was found in the expression of cyclin H and CDK7 protein between involuting hemangiomas and normal skin tissues (P > 0.05).</p><p><b>CONCLUSIONS</b>cyclin H and CDK7 may play an important role in the generation and development of human hemangiomas.</p>