Comparative genomic hybridization analysis of nonsyndromic cleft lip with palate / 中华整形外科杂志
Chinese Journal of Plastic Surgery
; (6): 123-125, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-325892
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To identify the genetic alterations in nonsyndromic cleft lip and palate (NSCLP).</p><p><b>METHODS</b>Comparative genomic hybridization was applied to investigate the genomic imbalance (the gain or loss of genetic material) in 7 cases of NSCLP.</p><p><b>RESULTS</b>It showed that the loss of chromosome DNA copies happened in chromosome 6, 7, 10, 13, 14, 16, 20, 22 and the gain of chromosome DNA copies happened in chromosome 5, 15, 18, 19. Conclusions 13q had a high frequency (71.4%) of chromosome loss.</p><p><b>CONCLUSIONS</b>Abnormal chromosome DNA copies happen in all the patients with NSCLP. Most of the patients have chromosome DNA copies loss. It suggests that loss of inhibitory gene may be related to the NSCLP. The related inhibitory gene may locate in 13q.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Genetic Variation
/
DNA
/
China
/
Cleft Lip
/
Cleft Palate
/
Ethnology
/
Comparative Genomic Hybridization
/
Genetics
/
Genotype
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Humans
/
Infant
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2008
Document type:
Article