Hyperacute Radiation Effect on Cerebral Cortex after Local Gamma-irradiation in the Rat Brain
Journal of Korean Neurosurgical Society
; : 370-374, 2005.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-32640
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
We investigated the morphologic changes within 24 hours after a single gamma-irradiation in the rat brain.METHODS:
Forty Sprague-Dawley rats were used. After a burr hole trephination on right parietal area, cerebral hemisphere was irradiated with 2Gy and 5Gy using iridium-192(192Ir), respectively. The effect was assessed at 4, 8, 12 and 24 hours after irradiation. The histological changes were scored following the detection of edema or disarray severity. TUNEL-positive cells exhibiting apoptotic morphology were counted in irradiated region.RESULTS:
Cortical edema and disarray were initially showed at 4 or 8hour and almost all defined at 24hour after irradiation. And the injury was wedge shape. TUNEL-positive cells were minimal at 8hour after irradiation as the number of positive cells were 2.6+/-5.27(n=5) after 2Gy, and 0.8+/-0.84(n=5) after 5Gy. But, the number of apoptotic cells were increased markedly to 60+/-6.24 at 12hour after 2Gy and to 104+/-19.7 at 24hour after 5Gy.CONCLUSION:
There were prominent morphologic changes immediately after gamma-irradiation. And, apoptosis was increased according to the time period. These findings implicate that brain irradiation induces rapid apoptotic change, which may play an important role in the pathogenesis of radiation-induced pathologic conditions.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Radiation Effects
/
Radiation Injuries
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Trephining
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Brain
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Cerebral Cortex
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Cranial Irradiation
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Rats, Sprague-Dawley
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Apoptosis
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Edema
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Cerebrum
Limits:
Animals
Language:
Korean
Journal:
Journal of Korean Neurosurgical Society
Year:
2005
Document type:
Article