Effect of guizhi decoction on CD4+, CD8+ T-lymphocytes and SIgA in mucosal immune system in intestine of mice with Bi syndrome (collagen induced immune arthritis) / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 336-338, 2004.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-326755
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of Guizhi Decoction (GZD) on immunological indexes in intestinal mucosal immune system of mice with Bi syndrome (collagen induced immune arthritis).</p><p><b>METHODS</b>Eighty male DBA mice were randomly divided into 4 groups, the normal group, the model group and the high and low dosage GZD groups. Model of Bi syndrome was induced by collagen type II. CD4+, CD8+ T-lymphocytes and SIgA in mice' small intestine and PP node were labeled by immunohistochemical staining and their number was calculated using imaging analyzer.</p><p><b>RESULTS</b>Compared with the normal group, in the model group, after immunization with collagen type II, numbers of CD4+ and CD8+ T-lymphocytes and SIgA in mice' intestinal mucosal immune system reduced significantly (P < 0.05 or P < 0.01). After treatment with GZD of both high and low dosage, CD4+ T-lymphocytes and SIgA increased significantly, but significant difference only showed in comparison between the high dosage GZD group and the model group (P < 0.05 or P < 0.01).</p><p><b>CONCLUSION</b>GZD could enhance the immune function in intestinal mucosa in mice with Bi syndrome, thus it might induce immune tolerance and immune inhibition.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Arthritis, Experimental
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Immunoglobulin A, Secretory
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Drugs, Chinese Herbal
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CD4-Positive T-Lymphocytes
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Random Allocation
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Adjuvants, Immunologic
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CD8-Positive T-Lymphocytes
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Immunity, Mucosal
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Allergy and Immunology
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2004
Document type:
Article