Association of the polymorphisms in the promoter region of tumor necrosis factor alpha and interleukin 6 genes with schizophrenia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 427-431, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-326917
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between the -308G/A, -857C/T and -1031T/C of tumor necrosis factor alpha gene (TNF- alpha), -174G/C and -572C/G of interleukin-6 gene (IL-6) polymorphisms and schizophrenia.</p><p><b>METHODS</b>Genomic DNA was isolated from the venous blood leukocytes of 346 unrelated patients with schizophrenia and 323 healthy unrelated individuals (control group). All of the polymorphisms were genotyped by PCR-restriction fragment length polymorphisms (PCR-RFLP). Genotype and allele frequencies were analyzed by SPSS13.0 software.</p><p><b>RESULTS</b>There were significant differences in both allele and genotype frequencies of -857C/T of TNF-alpha gene between the schizophrenia and control groups (P< 0.05). The allele T of -857C/T in schizophrenia group was significantly higher than that in control group (chi-square was 9.414, P=0.002, OR=1.511, 95%CI1.160-1.969). In addition, there were significant differences in the positive and negative syndrome scale (PANSS) total score and negative symptoms between the patients with different -857C/T genotypes, and the negative symptom score of TT genotype was significantly higher than that of CC genotype (P<0.05).</p><p><b>CONCLUSION</b>There is an association between -857C/T of TNF-alpha gene and schizophrenia, individuals with T allele of -857C/T are susceptible to schizophrenia, and there is an association between -857C/T and negative symptom score.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Polymorphism, Genetic
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Schizophrenia
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Polymorphism, Restriction Fragment Length
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Case-Control Studies
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Polymerase Chain Reaction
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Interleukin-6
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Promoter Regions, Genetic
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Tumor Necrosis Factor-alpha
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Gene Frequency
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2011
Document type:
Article