The TGF-alpha gene Taq I polymorphism and non-syndromic cleft lip with or without cleft palate / 中华整形外科杂志
Chinese Journal of Plastic Surgery
; (6): 190-193, 2004.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-327278
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the association of TGF-alpha gene Taq I polymorphism and nonsyndromic cleft lip with or without cleft palate (NSCL/P) in Chinese.</p><p><b>METHODS</b>107 patients with NSCL/P and 136 healthy controls were examined for TGF-alpha/Taq I genotypes. TGF-alpha/Taq I typing was carried out by digesting the locus specific polymerase chain reaction amplified products with alleles specific Taq I restriction enzyme (PCR-RELP).</p><p><b>RESULTS</b>The C2 allele frequency of TGF-alpha/Taq I in patients with NSCL/P (16%) was significantly higher than that in healthy controls (8%). The C2 genotype frequency of TGF-alpha/Taq I in NSCL/P patients with positive family history (12.5%) was significantly higher than that in healthy controls.</p><p><b>CONCLUSION</b>These findings demonstrate the role of TGF-alpha as a gene of major effects in the development of nonsyndromic cleft lip with or without cleft palate clefts in human. These findings suggest that a family history of clefting may correlate with the TGF-alpha Taq I rare variation.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Polymorphism, Restriction Fragment Length
/
DNA
/
China
/
Polymerase Chain Reaction
/
Transforming Growth Factor alpha
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Cleft Lip
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Cleft Palate
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Taq Polymerase
/
Gene Frequency
Limits:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2004
Document type:
Article