Prognostic value of lymph node ratio in hypopharyngeal squamous cell carcinoma after chemoradiotherapy / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 4139-4144, 2013.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-327618
Responsible library:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Lymph node ratio (LNR) has recently been reported as a potential prognostic marker in many malignant diseases. We aimed to analyze the potential prognostic effect of LNR on hypopharyngeal squamous cell carcinoma (HPSCC) after neoadjuvant therapy in our institution.</p><p><b>METHODS</b>We performed a retrospective study of 279 patients with HPSCC who underwent radiotherapy with or without chemotherapy followed by neck dissection between November 1965 and December 2008. Patients were divided into four groups according to quartiles based on LNR.</p><p><b>RESULTS</b>The mean LNR was 10.4% (range 0-100%, median 4.3%). Males and advanced clinical N classification significantly increased the LNR (P = 0.014 and P < 0.001, respectively). Compared with those with LNR <0.14, LNR ≥0.14 was associated with reduced overall, disease-specific and disease-free survival (all at P < 0.001). Multivariate analysis revealed that LNR is an independent predictor of prognosis.</p><p><b>CONCLUSION</b>Our results suggest that LNR is a strong predictor of HPSCC after chemoradiotherapy.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Radiotherapy
/
Carcinoma, Squamous Cell
/
Hypopharyngeal Neoplasms
/
Retrospective Studies
/
Disease-Free Survival
/
Drug Therapy
/
Chemoradiotherapy
/
Head and Neck Neoplasms
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Aged, 80 and over
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2013
Document type:
Article