Expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and their significances / 中华血液学杂志
Chinese Journal of Hematology
; (12): 661-665, 2006.
Article
in Zh
| WPRIM
| ID: wpr-328404
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and its significance.</p><p><b>METHODS</b>CYR61 mRNA and VEGF mRNA were detected by real-time fluorescence quantitative PCR method in 20 cases of extranodal nasal-type NK/T cell lymphoma. Expressions of CYR61 and VEGF were studied by immunohistochemistry in 40 cases of the tumor.</p><p><b>RESULTS</b>(1) Over-expression of CYR61 mRNA and VEGF mRNA was found in 19/20(95.0% ) and 15/20(75.0% ) cases, respectively. (2)Tumor cells expressing CYR61 protein and VEGF protein were detected in 38(95.0% ) and 25 (62. 5% ) of the 40 cases respectively, being no significant difference from the control. Co-expression of CYR61 and VEGF at both the mRNA and protein levels was 95.0% and 65.0% , respectively. Over-expression of CYR61 and VEGF at both mRNA and protein levels was found in 8 of the 40 cases. (3) The prognosis of the patients over-expressing CYR61 and VEGF was worse.</p><p><b>CONCLUSION</b>In extranodal nasal-type NK/T cell lymphoma, the expression level of CYR61 and VEGF was changed and it may be of prognostic implication of</p>
Full text:
1
Database:
WPRIM
Main subject:
Pathology
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RNA, Messenger
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Killer Cells, Natural
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Nose Neoplasms
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Polymerase Chain Reaction
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Lymphoma, T-Cell
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Immediate-Early Proteins
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Intercellular Signaling Peptides and Proteins
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Vascular Endothelial Growth Factor A
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Cysteine-Rich Protein 61
Type of study:
Prognostic_studies
Limits:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Hematology
Year:
2006
Document type:
Article