Study of methylation of promoter of EYA1 gene in microtia / 中华整形外科杂志
Chinese Journal of Plastic Surgery
; (6): 436-439, 2009.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-328653
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the methylation of CpG islands in promoter of eye absent gene 1 (EYA1) in microtia.</p><p><b>METHODS</b>The methylation of CpG islands in EYA1 gene in 64 microtias and 36 healthy controls were measured using the technique of matrix-assisted laser desorption/ionization-time of flight.</p><p><b>RESULTS</b>The methylation of CpG_Unit3 and CpG_Unit5 of EYA1 gene in microtia were 0.09258 +/- 0.033846 and 0.0922 +/- 0.02379, respectively, which were significantly lower than those in control.</p><p><b>CONCLUSIONS</b>Hypomethylation in microtia may be related to the pathogenesis of the disease.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Congenital Abnormalities
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Nuclear Proteins
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Promoter Regions, Genetic
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Protein Tyrosine Phosphatases
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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CpG Islands
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DNA Methylation
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Intracellular Signaling Peptides and Proteins
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Ear
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Genetics
Limits:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2009
Document type:
Article