Analysis of HLA-DRB1,DQB1 allele polymorphism in the Kunming Yi nationality population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 522-523, 2004.
Article
in Zh
| WPRIM
| ID: wpr-328833
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the HLA-DRB1, DQB1 allele polymorphism in Kunming Yi nationality population.</p><p><b>METHODS</b>HLA-DRB1, DQB1 DNA types in 70 healthy children of Yi nationality in Kunming were analyzed by polymerase chain reaction with sequence specific primer (PCR-SSP).</p><p><b>RESULTS</b>Twelve alleles at HLA-DRB1 locus were observed in the 70 children: the alleles with gene frequencies higher than 10% were HLA-DRB1*12(33.57%), DRB1*0901(11.43%), DRB1*04(11.43%); the alleles with gene frequencies between 10% and 5% were HLA-DRB1*01(8.57%), DRB1*11(7.86%), DRB1*14(7.14%), DRB1*15(7.14%), DRB1*08(5%); the alleles with gene frequencies lower than 5% were HLA-DRB1*03(2.86%), DRB1*13(2.14%), DRB1*07(1.43%), DRB1*16(1.43%). Seven alleles at HLA-DQB1 locus were observed in the 70 children: the alleles with gene frequencies higher than 10% were HLA-DQB1*0301(45%), DQB1*05(22.14%), DQB1*0303(12.14%); the alleles with gene frequencies between 10% and 5% were HLA-DQB1*04(6.43%), DQB1*06(6.43%); the alleles with gene frequencies lower than 5% were HLA-DQB1*0201(4.29%) and DQB1*0302(3.57%).</p><p><b>CONCLUSION</b>The distribution of HLA-DRB1, DQB1 allele polymorphism in the Kunming Yi nationality population is distinctive. It is neither like that in the South Han population nor like that in the North Han population.</p>
Full text:
1
Database:
WPRIM
Main subject:
Polymorphism, Genetic
/
HLA-DQ Antigens
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HLA-DR Antigens
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China
/
Alleles
/
HLA-DQ beta-Chains
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HLA-DRB1 Chains
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Genetics
Limits:
Humans
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2004
Document type:
Article