Identification of G6PD gene variants from Hakka population in Guangdong province / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 448-451, 2004.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-328853
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Studying on G6PD polymorphism from Hakka population in Guangdong province.</p><p><b>METHODS</b>Identifying the variants of G6PD gene and determining the frequencies respectively with the use of amplified refractory mutation system(ARMS), polymerase chain reaction-single strand conformation polymorphism(PCR-SSCP) and ABI 3100 DNA sequencing technologies.</p><p><b>RESULTS</b>Mutations of G6PD gene in cDNA 1388 (G-->A), 1376 (G-->T), 95 (A-->G), 392 (G-->T), 1024 (C-->T), 1311 (C-->T) have been found.</p><p><b>CONCLUSION</b>G6PD cDNA 1388 (G-->A), 1376 (G-->T), 95(A--> G), 392 (G-->T), 1024 (C-->T) and 1311 (C-->T) accompanied with intron 11 (93 T-->C) are the common mutations in Chinese population. cDNA 1388 (G-->A), cDNA 1376 (G-->T) are the most popular G6PD gene variants in Hakka population. In this study, no new type of G6PD gene mutation was found in the Hakkas of Guangdong.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
DNA Mutational Analysis
/
Introns
/
China
/
Polymerase Chain Reaction
/
Sequence Analysis, DNA
/
Polymorphism, Single Nucleotide
/
Asian People
/
Ethnology
/
Genetics
/
Glucosephosphate Dehydrogenase
Type of study:
Diagnostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2004
Document type:
Article