Study on the genic polymorphism of HLA-DRB1 in a population in the north of China / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 325-327, 2003.
Article
in Zh
| WPRIM
| ID: wpr-329470
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate at the DNA level the polymorphism of HLA-DRB1 gene in Han population in Beijing of China.</p><p><b>METHODS</b>This study was conducted in the Hans in Beijing. A total of 2810 normal and unrelated neonates were analyzed and subjected to HLA-DRB1 low resolution typing, and from among them 217 neonates were randomly selected for DRB1 high resolution typing by polymerase chain reaction-sequence specific primers technique.</p><p><b>RESULTS</b>Fourteen HLA-DRB1 specificity and 39 alleles were found with HLA-DRB1 *09012, *1501, *07011, *08032 as the most common genes. Their gene frequencies and allelic distributions were compared to those observed in other ethnic populations.</p><p><b>CONCLUSION</b>The results showed the characteristic of HLA-DRB1 distribution, and provided more comprehensive and accurate gene data that may serve as normal reference values for the population in Beijing, China.</p>
Full text:
1
Database:
WPRIM
Main subject:
Polymorphism, Genetic
/
HLA-DR Antigens
/
China
/
Polymerase Chain Reaction
/
Asian People
/
HLA-DRB1 Chains
/
Gene Frequency
/
Genetics
/
Genetics, Population
Limits:
Female
/
Humans
/
Male
/
Newborn
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2003
Document type:
Article