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Intrauterine infections and birth defects / 生物医学与环境科学(英文)
Article in English | WPRIM (Western Pacific) | ID: wpr-329612
Responsible library: WPRO
ABSTRACT
Intrauterine infection is an important cause of some birth defects worldwide. The most common pathogens include rubella virus, cytomegaloviurs, ureaplasma urealyticum, toxoplasma, etc. General information about these pathogens in epidemiology, consequence of birth defects, and the possible mechanisms in the progress of birth defects, and the interventions to prevent or treat these pathogens' infections are described. The infections caused by rubella virus, cytomegaloviurs, ureaplasma urealyticum, toxoplasma, etc. are common, yet they are proved to be fatal during the pregnant period, especially during the first trimester. These infections may cause sterility, abortion, stillbirth, low birth weight, and affect multiple organs that may induce loss of hearing and vision, even fetal deformity and the long-term effects. These pathogens' infections may influence the microenvironment of placenta, including levels of enzymes and cytokines, and affect chondriosome that may induce the progress of birth defect. Early diagnosis of infections during pregnancy should be strengthened. There are still many things to be settled, such as the molecular mechanisms of birth defects, the effective vaccines to certain pathogens. Birth defect researches in terms of etiology and the development of applicable and sensitive pathogen detection technology and methods are imperative.
Subject(s)
Full text: Available Health context: Neglected Diseases Health problem: Zoonoses Database: WPRIM (Western Pacific) Main subject: Placenta Diseases / Pregnancy Complications, Infectious / Pregnancy Trimester, First / Rubella / Congenital Abnormalities / Toxoplasma / Virulence / Pregnancy Outcome / Ureaplasma urealyticum Type of study: Screening study Limits: Animals / Female / Humans / Pregnancy Language: English Journal: Biomedical and Environmental Sciences Year: 2004 Document type: Article
Full text: Available Health context: Neglected Diseases Health problem: Zoonoses Database: WPRIM (Western Pacific) Main subject: Placenta Diseases / Pregnancy Complications, Infectious / Pregnancy Trimester, First / Rubella / Congenital Abnormalities / Toxoplasma / Virulence / Pregnancy Outcome / Ureaplasma urealyticum Type of study: Screening study Limits: Animals / Female / Humans / Pregnancy Language: English Journal: Biomedical and Environmental Sciences Year: 2004 Document type: Article
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