The expression of MMP-9, MMP-2 in the remodeling bone tissue around implant during unloaded period / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To discuss the function of MMP-9, MMP-2 in the remodeling bone tissue around implant during unloaded period.</p><p><b>METHODS</b>At the anterior of the maxilla and mandibular of the Beagle dog, implants were placed at different periods, so the implant specimens of different periods were obtained after dogs were killed. The implant specimens were removed, fixed in 4% paraformaldehyde for 24 hours at 4 degrees C, decalcified with 10% EDTA at pH 7.2, embedded in paraffin wax and sectioned. The observation of the expression changes of the MMP-2, MMP-9 in the milien bone tissue of the implant at different periods were taken by immunohistochemical staining.</p><p><b>RESULTS</b>Matrix metalloprotainase (MMP-9) was mostly expressed at the peripheral cytoplasmic of osteoclast, macrophage, lining cell and fibroblast. MMP-2 was mostly expressed at the peripheral cytoplasmic of osteoblast, fibroblast, some osteoclast also expressed this enzyme.</p><p><b>CONCLUSION</b>MMP-2 and MMP -9 have an important function at the injured bone absorption, healing and bone remodeling after dental implant placement.</p>