Heat shock protein 70 gene polymorphisms in Han nationality of China with chronic obstructive pulmonary diseases / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
; (6): 28-31, 2004.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-330880
Responsible library:
WPRO
ABSTRACT
In order to investigate whether polymorphism in gene for heat shock protein 70 (HSP70) has any bearing on individual susceptibility to the development of chronic obstructive pulmonary disease (COPD), the geotypes of 88 patients with COPD and 87 healthy smoking control subjects were tested by polymerase chain reaction followed by restriction fragment polymorphism analysis for HSP70 gene. In COPD group, HSP70-1 genotype A/A, A/B and B/B was 59.1%, 35.2% and 5.7%, HSP70-2 genotype A/A, A/B and B/B was 26.1%, 54.6% and 19.3%, and HSP70-hom genotype A/A, A/B and B/B was 70.4%, 27.3% and 2.3% respectively. In the control group, it was 60.9%, 27.5% and 3.5%, 20.7%, 56.3% and 23.0%, and 54.0%, 42.5% and 3.5%, respectively. The frequency of polymorphic genetypes showed no difference between the COPD group and the control group (P>0.05). It was suggested that geneic polymorphism in HSP70 is not associated with development of COPD in Han nationality of China.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Restriction Fragment Length
/
Ethnicity
/
Smoking
/
China
/
HSP70 Heat-Shock Proteins
/
Genetic Predisposition to Disease
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Pulmonary Disease, Chronic Obstructive
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Ethnology
/
Genetics
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Year:
2004
Document type:
Article