Prognostic factors and treatment of 74 patients with dermatofibro-sarcoma protuberans / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 122-125, 2005.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-331212
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze treatment and prognostic factors of 74 patients with dermatofibro-sarcoma protuberans (DFSP).</p><p><b>METHODS</b>From August 1990 to November 1999, 74 patients with DFSP confirmed pathologically were treated. There were 52 males and 22 females with a median age of 37 years (range 4 to 80 years) on diagnosis. Seventeen patients were treated by extensive excision and 2 by limited excision. Fifty-two patients had surgical resection alone (S), and 22 postoperative radiotherapy (S + R) of 50-70 Gy. The multivariate parameters were analyzed using Cox model. Kaplan-Meier and Log-Rank test were used to evaluate the results of the recurrence-free survival.</p><p><b>RESULTS</b>The rate of recurrence was 28.4% for all patients. The 5-year recurrence-free survival rate (RFSR) was 66.6% and the 10-year RFSR was 52.5%. The 5-year and 10-year in the S group were 58.4% and 41.2%, compared with 90.0% and 83.3% in the S + R group (P < 0.05). The 5-year and 10-year RFSR in the pathologically positive margin group were 57.5% and 41.4% respectively, compared with the 75.0% and 56.6% in the pathologically negative group (P < 0.05). Multivariate analysis suggested radiotherapy and negative pathological margins were favorable prognostic factors.</p><p><b>CONCLUSION</b>Post-operation radiotherapy and pathological margin are the independent prognostic factors.</p>
Full text:
Available
Health context:
SDG3 - Health and Well-Being
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SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
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SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Target 3.2: Reduce avoidable death in newborns and children under 5
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Skin Diseases
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Noncommunicable Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Postoperative Care
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Prognosis
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Radiotherapy
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Skin Neoplasms
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General Surgery
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Proportional Hazards Models
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Retrospective Studies
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Follow-Up Studies
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Mortality
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Dermatofibrosarcoma
Type of study:
Observational study
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Prognostic study
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Risk factors
Limits:
Adolescent
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Adult
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Aged
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Aged, 80 and over
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Child
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Child, preschool
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Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2005
Document type:
Article