Phase II study of paclitaxel and cisplatin for advanced squamous-cell carcinoma of esophagus / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 753-755, 2004.
Article
in Zh
| WPRIM
| ID: wpr-331258
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Paclitaxel was used in a phase II trial in combination with cisplatin for esophageal cancer. The anti-tumor response, toxicity and survival of the treated patients were evaluated.</p><p><b>METHODS</b>Thirty patients with advanced, unresectable, or complicated with metastasis were allotted, twenty-seven patients had no prior chemotherapy while 3 patients had received adjuvant chemotherapy. Patients were given paclitaxel 175 mg/m(2) by 3-hour infusion on D1, and cisplatin 40 mg/m(2) daily on D2 and D3. Granulocyte colony-stimulating factor (G-CSF) was not routinely administered unless the patient had neutropenia. Treatment was recycled every 21 days.</p><p><b>RESULTS</b>Thirty patients (male/female, 28/2; median age 58) completed a median of 3 cycles and 27 patients were evaluable for response. Major objective responses were observed in 16 patients (59.3%; 95% confidence interval, 38.9% to 75.5%), including 5 complete responses (18.5%) and 11 partial responses (40.7%). The median time to tumor progression was 5.0 months (range, 1 to 23 months). The median actuarial survival was 9.7 months (range, 1 to 23 months). Twenty-eight patients were assessable for toxicity. The most common nonhematologic toxicity was alopecia. Grade 3 to 4 neutropenia was observed in 17.9% of the patients. Toxicity was manageable with dose attenuation and G-CSF support.</p><p><b>CONCLUSION</b>The combination of paclitaxel and cisplatin can be considered as a main regimen in the treatment of advanced esophageal cancer.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Remission Induction
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Drug Administration Schedule
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Esophageal Neoplasms
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Carcinoma, Squamous Cell
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Antineoplastic Combined Chemotherapy Protocols
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Survival Rate
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Cisplatin
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Paclitaxel
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Therapeutic Uses
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Oncology
Year:
2004
Document type:
Article