Preparation of biodegradable and sustained release gel of tinidazole / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 87-90, 2007.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-331389
Responsible library:
WPRO
ABSTRACT
The objective of this study was to prepare a biodegradable poly (DL-lactide) injectable gel of tinidazole. The formulation parameters evaluated in this study included polymer molecular weight, polymer concentration, solvent and drug loading, and orthogonal design was used to optimize the formulation. The preferable formulation was that 30% (w/w) poly(DL-lactide) (MW is 5 700) dissolved in 70% (w/w) N-methyl-2-pyrrolidone with 4%-6% (w/w) tinidazole.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Polyesters
/
Polymers
/
Tinidazole
/
Drug Carriers
/
Chemistry
/
Technology, Pharmaceutical
/
Lactic Acid
/
Delayed-Action Preparations
/
Gels
/
Methods
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2007
Document type:
Article