Security evaluation of subcutaneous injection with water-based dextran-coated magnetic fluid / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 1275-1278, 2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-331431
Responsible library:
WPRO
ABSTRACT
Water-based magnetic fluid was synthesized by using 50% dextran 40,000 as coated reagent. The acute toxicity and irritant of the magnetic fluid injected into mice subcutaneous tissues were examined. The lethal dosage 50 of dextran-coated magnetic fluid was 4409.61 +/- 514.93 mg/kg. Twenty four h after subcutaneous injecting with 30 mg/0.3 ml dextran-coated magnetic fluid, no more inflammation than hemangiectasia and leucocytes infiltration had been seen in subcutaneous tissues, 72 h later the reaction phenomena disappeared. While, injection with 30 mg/0.3 ml water-based oleate sodium-coated magnetic fluid, ulceration and break-off of cutis had been seen in the seventh days. That is to say, the dextran-coated magnetic fluid was safe and well tolerate, however, the oleate sodium-coated magnetic fluid was not fit to subcutaneous injection.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Random Allocation
/
Dextrans
/
Coated Materials, Biocompatible
/
Ferrosoferric Oxide
/
Toxicity
/
Injections, Subcutaneous
/
Magnetics
/
Mice, Inbred BALB C
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2006
Document type:
Article