Study on the relationship between polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the relationship between the polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia.</p><p><b>METHODS</b>ApoE genotype of 102 patients with hyperlipemia was detected by gene PCR sequencing.</p><p><b>RESULTS</b>A total of five genotypes were detectable, they were E2/2, E3/3, E4/4, E2/3 and E3/4. The frequency of E3/4 + E4/4 and epsilon4 allelotype detected in the patients of Gan-Shen Yin deficiency syndrome type were significantly higher than those in patients of Pi-Shen Yang-deficiency type or of phlegm stagnation type (P < 0.05, P < 0.01), and which in patients of Qi-stagnation caused blood stasis type were significantly higher than those in patients of phlegm stagnation type ( P < 0.05).</p><p><b>CONCLUSION</b>Polymorphism of ApoE gene is related in a certain degree to TCM syndrome type of primary hyperlipemia.</p>