Expression of c-fos, OPG, OPGL in rabbit mandibular distraction osteogenesis zone / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 496-500, 2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-332117
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the possible signal transduction mechanism of the mechanical stress induced by the distraction procedure in osteocytes.</p><p><b>METHODS</b>An animal model of mandibular distraction osteogenesis in rabbits was established. The expressions of c-fos, OPG and OPGL were detected by ultrasensitive S-P immunohistochemical method.</p><p><b>RESULT</b>At 4 and 8 days after distraction, distraction zone showed strong positive staining of c-fos, which were apparently higher than that in distraction zone of 2, 4 and 6 weeks after consolidation. At 4 and 8 days after distraction and 2 weeks after consolidation, the expression of OPG was strong, and then wore off gradually at 4 and 6 weeks after consolidation. Weak signals of OPGL could be detected at 6 weeks after consolidation only.</p><p><b>CONCLUSION</b>c-fos, OPG and OPGL are important regulators in distraction osteogenesis. c-fos is interrelated with the mechanical stress induced by the distraction procedure closely, OPG promotes new bone formation, while OPGL plays a more active role in bone remodeling.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Osteocytes
/
Random Allocation
/
Proto-Oncogene Proteins c-fos
/
Osteogenesis, Distraction
/
Cell Biology
/
RANK Ligand
/
Osteoprotegerin
/
Genetics
/
Mandible
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2006
Document type:
Article