Effects of paclitaxel loaded ultrasound contrast agents on cell cycles and ultrastructural features of HepG2 cells / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 360-362, 2008.
Article
in Zh
| WPRIM
| ID: wpr-332234
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVES</b>To investigate the effects of paclitaxel loaded ultrasound contrast agents on cell cycles and ultrastructural features of HepG2 cells.</p><p><b>METHODS</b>HepG2 cells were cultured, and divided into a blank control group, a paclitaxel group, an ultrasound contrast agents group, and a paclitaxel loaded ultrasound contrast agents group. Cell cycles of the four groups were detected by flow cytometry, and the ultrastructural changes of the cells were observed under a transmission electron microscope.</p><p><b>RESULTS</b>Paclitaxel loaded ultrasound contrast agents blocked the HepG2 cells at their G2/M phases, and it also induced more apoptosis of the HepG2 cells.</p><p><b>CONCLUSIONS</b>Paclitaxel loaded ultrasound contrast agents can block HepG2 cells at the G2/M phase and induce apoptosis of the cells.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pharmacology
/
Cell Cycle
/
Paclitaxel
/
Apoptosis
/
Contrast Media
/
Microscopy, Electron, Transmission
/
Hep G2 Cells
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Hepatology
Year:
2008
Document type:
Article