Evaluation of the ELISA and the enhanced chemiluminescence immunoassay in use to determine the serum markers for liver fibrosis / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 71-73, 2009.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-332425
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the detection method of ELISA and Enhanced Chemiluminescence Immunoassay (ECLIA) in use to determine serum hyaluronate acid (HA), laminin (LN), type IV collagen (IV-C) and type III procollagen (PC III).</p><p><b>METHODS</b>253 patients with chronic hepatitis B were determined the four liver fibrosis serum markers with both the ECLIA and ELISA, and then compared with pathology results separately.</p><p><b>RESULTS</b>Both the detection results of ELISA and ECLIA can reflect that the patient's liver fibrosis from hepatitis to liver cirrhosis aggravated gradually. Compared with ELISA, the results of ECLIA and pathology have a better correlation.</p><p><b>CONCLUSIONS</b>The detection of four liver fibrosis serum markers by ECLIA could indicate the better the response of the state of live fibrosis.</p>
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Cirrhosis
/
Digestive System Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Blood
/
Enzyme-Linked Immunosorbent Assay
/
Biomarkers
/
Laminin
/
Collagen Type III
/
Collagen Type IV
/
Diagnosis
/
Liver Cirrhosis
/
Luminescent Measurements
Type of study:
Diagnostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2009
Document type:
Article