Relationship between fatal severe from hepatitis occurred during chronic hepatitis B and superinfections of hepatotropic B e system status / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 52-54, 2005.
Article
in Zh
| WPRIM
| ID: wpr-333051
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To clarify the relationship between fatal severe form hepatitis occurred during chronic hepatitis B and superinfections of hepatitis A, C, D or E virus as well as hepatitis B e system status and to adopt corresponding measures to reduce the mortality of chronic hepatitis B.</p><p><b>METHODS</b>This study detected the superinfections with hepatitis A, C, D or E virus and hepatitis B e system status in 219 patients with fatal severe form hepatitis occurred during chronic hepatitis B by enzyme linked immunosorbent assay.</p><p><b>RESULTS</b>The superinfections with hepatitis A, C, D or E virus were found in 1.4% (3/219), 9.6% (21/219), 1.8% (4/219) and 30.1% (66/219) of the patients, respectively, altogether 42.9% (94/219); hepatitis E was prominent and steady in superinfection rate in recent ten years. The causes of 57.1% (125/219) patients were not clear. The positive rate of HBeAg and anti-HBe were 17.0% (16/94) and 54.2% (51/94) in the group of superinfections with hepatitis A, C, D or E virus; and were 27.2% (34/125) and 47.2% (59/125) in the group with unknown causes, respectively.</p><p><b>CONCLUSION</b>These results suggested that the patients with superinfections reached 42.9% (94/219), and the superinfections may be a part of causes of fatal severe form hepatitis, and the mortality of chronic hepatitis B may be decreased by strict food sanitation and use of safe blood products. There were no significant relation between hepatitis B e antigen seroconversion and the fatal severe form hepatitis occurred during chronic hepatitis B.</p>
Full text:
1
Database:
WPRIM
Main subject:
Physiology
/
Virology
/
Blood
/
DNA, Viral
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Hepatitis Delta Virus
/
Superinfection
/
Hepatitis B virus
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Survival Rate
/
Mortality
/
Hepatitis E virus
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2005
Document type:
Article