Soft tissue regeneration after implantation of two novel citric acid-based biodegradable materials in rats / 南方医科大学学报
Journal of Southern Medical University
; (12): 1184-1188, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-333659
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the soft tissue regeneration after implantation of two novel citric acid-based biodegradable materials in the skull defects in rats.</p><p><b>METHODS</b>Two novel citric acid-based biodegradable materials were implanted in the muscular tissues in the thigh and harvested 2 weeks later. Another 40 rats with surgically induced cranial defect were randomized into control group, autograft group, CUPE-HA group, and POC-HA group (n=10), and 3 months after implantation, the materials were harvested for histological and morphometric analyses.</p><p><b>RESULTS</b>Soft tissue regeneration was stimulated by the two biodegradable materials in the muscular tissues. The implants also stimulated angiogenesis and soft tissue regeneration in the cranial defect and accelerated of intramembranous ossification.</p><p><b>CONCLUSION</b>The 2 novel citric acid-based biodegradable materials can induce angiogenesis and soft tissue regeneration and accelerate intramembranous ossification in rats with cranial defects.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Regeneration
/
Skull
/
Therapeutics
/
Wound Healing
/
Soft Tissue Injuries
/
Neovascularization, Physiologic
/
Citric Acid
/
Absorbable Implants
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2015
Document type:
Article